In a previous study Perry and Mount found a significant increase in resistance level in 10 subjects following intramuscularly administered atropine as compared to a placebo injection.1 In each subject the placebo was given before atropine. The results of subsequent studies indicate that the magnitude of the order effects is not sufficient to alter the general form of the results for any of the drugs considered to date.* In the present study the effect on skin resistance of injections of methantheline bromide (Banthine) and propantheline bromide (Pro-Banthine) have been compared to a placebo.
The subjects were 10 normal white males ranging from 19 to 35 years of age. Each subject received one injection in each of three experimental periods. The time between the experiments varied from 3 to 15 days. The injections consisted of 10 mg. of methantheline bromide and 5 mg. of propantheline