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Article
April 1955

FAVORABLE RESPONSE OF NECROBIOSIS LIPOIDICA DIABETICORUM TO HYDROCORTISONE SUSPENSION

Author Affiliations

Los Angeles

AMA Arch Derm. 1955;71(4):506. doi:10.1001/archderm.1955.01540280082019
Abstract

Inasmuch as necrobiosis lipoidica diabeticorum is difficult to treat, I feel justified in reporting the response of a single case to injections of hydrocortisone suspension.

E. M., a 25-year-old white housewife, presented herself to me in December, 1949, complaining of an hourglass-shaped lesion on her right leg, present since 1946. Clinical appearance and biopsy were those of necrobiosis lipoidica diabeticorum. The patient's maternal aunt and grandfather had diabetes. The patient's urinalysis and glucose-tolerance tests were normal. The lesion was frozen with solid carbon dioxide for four successive weeks, without improvement, and then irradiated with 75 r of x-ray (factors not available) by another dermatologist for four successive weeks, without success. The patient returned in March, 1952, at which time a preparation was prescribed for local use, consisting of 500 mg. of cortisone in 20 gm. of polyethylene glycol 1500 (Carbowax 1500), as recommended by Newman and

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