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April 1955


AMA Arch Derm. 1955;71(4):537-540. doi:10.1001/archderm.1955.01540280113033

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Addison's Disease Treated with Hydrocortisone and Desoxycorticosterone Acetate. Presented by Dr. George M. Stroud.

Mrs. A. W., a 53-year-old housewife, developed dark brown pigmentation of widespread areas of the skin six months ago. This was followed by nausea, vomiting, and weakness, which became so severe that she was admitted in emergency to University Hospitals three months later.

She has shaved her face because of hirsutism since an attack of typhoid fever, followed by scarlet fever, 38 years ago. In 1944 a tuberculous left kidney was removed. There is no history of tuberculosis elsewhere.

Examination shows a diffuse or mottled light brown pigmentation of the forehead, cheeks, neck, waist (by history), cubital fossae, elbows, part of the extensor surface of the forearms, dorsum of hands, palmar folds, knees, and dorsum of feet. Blood pressure was 100/60.

Significant laboratory findings: Hemoglobin 12 gm. per 100 cc.; white cell count 3,500 per cubic

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