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May 1955


AMA Arch Derm. 1955;71(5):648-650. doi:10.1001/archderm.1955.01540290088029

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Clinical Evaluation of Tetracycline in Pustular Dermatoses. Presented by Dr. Charles R. Rein.

A series of 106 patients with pustular dermatoses were treated with orally administered tetracycline. Of this group 90 patients were maintained on therapy of 1 gm. per day in four divided doses over a period of four weeks.

Tetracycline was of definite value in that 42.2% had a marked improvement, 44.4% had a moderate improvement, and 13.3% showed a slight improvement.

Adverse reactions appeared to be less frequent and less severe than with previously employed broad-spectrum antibiotics, and consisted of nausea, vomiting, cramps, flatus, diarrhea, anogenital pruritus, hairy tongue, stomatitis, and burning sensation in the throat.

Tetracycline serum concentrations determined at varying intervals following completion of therapy gave measurable evidence of a cumulative effect.

Preliminary investigations with a new Monilia complement-fixation test seem to indicate that:

  • Tetracycline taken in doses of 1 gm. per day

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