Nodular Vasculitis. Presented by the Staff of Harper Hospital.
The patient is a middle-aged Negro woman. She contracted syphilis at the age of 21. She received arsenic and bismuth injections over the next 11 years. Her serology is now reported as negative. The patient complains of fatigue and lesions of the legs. There is scarring in the inguinal region. There are two erythematous, tender nodules on the calf of the left leg and one on the calf of the right leg.
Laboratory examinations consisting of red blood cell counts, hemoglobin, white blood cell counts, urinalysis, and sedimentation rates were all within normal limits. The chest x-ray was reported as essentially normal.
The biopsy report was as follows: There is a deep-seated inflammation mainly in the septa of the fat. The infiltrate is mainly perivascular, and often associated with changes of the blood vessels. There is proliferation up to complete occlusion.
Courville CJ, Mopper C, Eyster WH. DETROIT DERMATOLOGICAL SOCIETY. AMA Arch Derm. 1955;71(5):654–655. doi:10.1001/archderm.1955.01540290094031
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.