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Article
July 1955

Juvenile Acanthosis Nigricans Associated with Pituitary Hypogonadism

AMA Arch Derm. 1955;72(1):63-67. doi:10.1001/archderm.1955.03730310065013
Abstract

Most patients having the juvenile type of acanthosis nigricans are otherwise normal, although they may be obese. However, in some of these patients endocrinologic abnormalities have been noted, such as acne vulgaris, glucosuria, diabetes mellitus, and hypofunction of the adrenal glands.* It has been postulated that in both the benign and the malignant form of acanthosis nigricans some growth-stimulating materials present in the blood stream may cause the characteristic skin changes. Recently a case of juvenile acanthosis nigricans was reported in which there was clinically a Cushing-syndrome-like picture associated with pituitary basophilism without adrenal hyperplasia and osteoporosis at autopsy.2 However, many of the features of a Cushing's syndrome were apparently lacking in this case, including abnormal endocrine laboratory tests and blood electrolyte abnormalities. We wish to present the following case as an example of the juvenile type of acanthosis nigricans associated with

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