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Article
July 1955

EVALUATION OF 9-a-FLUOROHYDROCORTISONE ACETATE IN THE TREATMENT OF VARIOUS INFLAMMATORY DERMATOSES

Author Affiliations

Los Angeles

From the Medcial Service, Veterans Administration Center, General Medical and Surgical Hospital, and the Division of Dermatology, Department of Medicine, University of California Medical Center.

AMA Arch Derm. 1955;72(1):69-71. doi:10.1001/archderm.1955.03730310071015
Abstract

Recently several derivatives of cortisone acetate and hydrocortisone acetate have been synthetized in which the 9-α-hydrogen atom is replaced by a halogen.* Data as yet unpublished † have indicated that the 9-α-fluoro-derivative of hydrocortisone acetate possessed approximately 13 times the antiinflammatory activity of hydrocortisone acetate.

MATERIALS AND METHODS

This paper deals with a clinical evaluation of the effects of 9-α-fluorohydrocortisone acetate in 64 patients with various dermatological conditions in all of whom an inflammatory component was present.

9-α-Fluorohydrocortisone acetate was administered both systemically and locally. Parenteral therapy consisted of the oral administration of 1 mg. tablets in a daily dosage of 1 to 9 mg. Local treatment consisted of the application of lotions or ointments containing 0.1% or 0.2% 9-α-fluorohydrocortisone acetate.‡ Two types of bases were used, one a plasticized petrolatum base § and the other a lotion.‖ In addition, lotions and ointments containing neomycin, 2.5 mg/gm.

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