It has been reasonably well shown that the regional lymph node plays an important role in the development of certain types of antibodies. The work of McMaster and Hudack1 and of Ehrich, Harris and their colleagues2 clearly indicates that antibody is made, at least in part, in the regional node, i. e., the node adjacent to the site of introduction of the antigen, and it is probably made there prior to its manufacture elsewhere.
The nature of the antibody in the delayed type of sensitization is still a matter for argument. We are assuming that practically all workers in this field would agree that the delayed types of allergic sensitization, which comprise the bacterial (tuberculin) and the eczematous (contact) varieties, are brought about by antibodies or an antibody-like material. While any remarks that we may make probably apply to both varieties of the
ROSTENBERG A, BEST WR. Studies in Eczematous Sensitizations: V. The Role of the Regional Lymph Node. AMA Arch Derm. 1955;72(3):221–228. doi:10.1001/archderm.1955.03730330001001
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