In 1945 Atlanta was confronted with an epidemic of tinea capitis due to Microsporum audouini, which lasted several years. Roentgen ray epilations on a large scale were neither practical nor popular, and therapeutic response to the usual fungicides was slow. In an effort to improve the prognosis, a systemic approach was sought with estrogenic hormones. This additional treatment improved the prognosis to such an extent that its usage appeared indicated routinely.
Ample evidence of the influence of hormones in tinea capitis due to M. audouini can be found in the literature. Occurrence of tinea capitis in the postpubertal person is higher than is generally realized, but the fungi involved are usually of the endothrix type. A search of the American literature revealed only 106 cases of culturally proved adult scalp ringworm.* Ten of these cases were due to M. audouini. None of 45 cases whose
DOBES WL. The Effect of Estrogenic Hormones on Tinea Capitis Due to M. Audouini. AMA Arch Derm. 1955;72(3):252–265. doi:10.1001/archderm.1955.03730330032005
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.