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Article
September 1955

PRELIMINARY CLINICAL TRIAL WITH PREDNISONE (METICORTEN) IN SYSTEMIC LUPUS ERYTHEMATOSUS

Author Affiliations

New York

From the Medical Service, Beth Israel Hospital.

AMA Arch Derm. 1955;72(3):276-278. doi:10.1001/archderm.1955.01540330056009
Abstract

Prednisone (Meticorten) and prednisolone (Meticortelone)* were recently reported as effective antirheumatic and anti-inflammatory agents.† Prednisone was administered to a patient with systemic lupus erythematosus after gradual but complete withdrawal from cortisone; at a later date, and while the disease was in remission, an abrupt stoppage of this new medication was followed by a recrudescence of many of the original clinical manifestations. Reinstitution of prednisone induced a further remission which has been maintained for almost six months.

REPORT OF A CASE

A 14-year-old Chinese girl was originally admitted to Beth Israel Hospital on Jan. 6, 1954, because of muscular and joint pains, "sore throat," and a daily fever reaching a peak temperature of 105 F, present for 10 days. Anorexia, generalized weakness, malaise, and progressive weight loss (about 15 lb.) had been observed for the past five months.

Physical examination revealed an acute and chronically

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