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October 1955

Dermatitis Herpetiformis (Duhring) Successfully Treated with Promacetin

Author Affiliations

New York

From Bellevue Hospital, New York UniversityBellevue Medical Center, and St. Clare's Hospital.

AMA Arch Derm. 1955;72(4):348-352. doi:10.1001/archderm.1955.03730340046009

Promacetin* (acetosulfone) has been used extensively, in relatively large doses and for long periods of time, in the treatment of leprosy.

Until recently, sulfapyridine has been the only effective treatment of dermatitis herpetiformis; notwithstanding its potential toxicity (agranulocytosis, etc.) it has remained for the past 15 years the treatment of choice because of its consistent beneficial results. The fact that it has been often used as a therapeutic test in this disease attests to its efficacy.† We have been continually searching for a drug which would be equally effective therapeutically, but less toxic. Promacetin in tablets administered orally, we believe, has almost given us the answer in the control, but not in the permanent cure, of this inveterate dermatosis. Goldman reported its use in the treatment of this disease in 1952.4

The beneficial results obtained in the treatment of the following 12

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