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December 1955

Cortisone and Corticotropin Treatment of Pemphigus: Experience with Twenty-Eight Cases Over a Period of Five Years

Author Affiliations

New York

From the Department of Dermatology, College of Physicians and Surgeons, Columbia University, and the Dermatology Service, The Presbyterian Hospital.

AMA Arch Derm. 1955;72(6):495-505. doi:10.1001/archderm.1955.03730360001001

Until the advent of cortisone and corticotropin (ACTH) no consistently effective treatment for pemphigus was available. Today it is generally recognized that corticosteroids given internally and more or less continuously on a long-term basis constitute the best treatment for all types of this disease. Although cortisone and corticotropin have proved to be lifesaving for many patients with pemphigus, these hormones are not curative, and the need for administering them for prolonged periods has raised a number of problems not ordinarily encountered in their short-term use. In severe cases of pemphigus the dosage must be high and often must be continued for many months in the face of formidable complications. Despite the attendant risks of long-term steroid therapy, however, there are now few physicians who would seriously question the advisability of its use in this otherwise almost invariably fatal disease.

Our experience with cortisone