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Article
December 1955

Prednisolone Topically and SystemicallyA Clinical Evaluation in Selected Dermatoses: Preliminary Report

AMA Arch Derm. 1955;72(6):547-549. doi:10.1001/archderm.1955.03730360053005
Abstract

Prednisolone and prednisone, formerly called metacortandralone and metacortandracin, are two new synthetic hormones, which, milligram for milligram, possess greater anti-inflammatory effect and activity than cortisone or hydrocortisone and do not produce sodium and fluid retention or potassium depletion.

Prednisolone is produced by dehydrogenation at Positions 1 and 2 of the hydrocortisone nucleus. It is an analogue of hydrocortisone, while prednisone is an analogue of cortisone and is produced by dehydrogenation at Positions 1 and 2 of the cortisone nucleus.

As part of a research project to determine the effects of the various corticosteroids on skin electrolytes, the following is a preliminary report on the clinical effects of both topical and oral administration of prednisolone in a variety of dermatologic disorders.

METHODS AND MATERIALS

Topical Administration.—Prednisolone in strengths of 0.25% and 0.5% was prepared in an ointment of petrolatum and liquid

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