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December 1955

Black Grain Maduromycosis Caused by Madurella Grisea: Report of the First North American Case and Its Response to Therapy with Diaminodiphenylsulfone

Author Affiliations


From the Department of Dermatology, University of Illinois College of Medicine.

AMA Arch Derm. 1955;72(6):550-555. doi:10.1001/archderm.1955.03730360056006

The purpose of this paper is to report the first case of maduromycosis caused by Madurella grisea to be found in North America and to call attention to the promising results observed using 4,4'-diaminodiphenylsulfone (D. D. S.) therapy.

Although a number of cases of black grain maduromycosis have been reported in the United States, none of these has been due to M. grisea. With the possible exception of one case reported from India, the very limited number of previously known cases of maduromycosis caused by M. grisea have all been reported from South America.

The historical aspect of maduromycosis has been adequately covered in the classical paper of Chalmers and Archibald1 in 1916 and by Gammel2 in 1927. Specifically the black grain maduromycoses have been excellently reviewed by Mackinnon.3 In view of these papers it will be sufficient here to mention only briefly the