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December 1955

Differential Diagnosis of Leukoplakia, Leukokeratosis, and Cancer in the Mouth

AMA Arch Derm. 1955;72(6):599. doi:10.1001/archderm.1955.03730360105022

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In this short monograph of 62 pages, another in the American Lecture Series, some unusual statistics are presented; distant foci of infection are incriminated as being causative of oral leucoplakia; a rare case is cited of white plaques in the mouth produced presumably by phenobarbital, and the name leucokeratosis is used for a "specific entity" which develops from leucoplakia and which, unless checked, becomes cancer.

According to the author, some evidence of leucoplakia can be demonstrated in 50% of all males and 10% of all females over 45 years of age, and almost 50% of all carcinomas of the face appear on the lips. Leucoplakia is said to be associated frequently with remote foci of infection, including prostatitis, pyelonephritis, etc. One can differentiate leucoplakia from syphilitic mucous patches by the fact that the latter are more frequently deeply ulcerated.

The book contains an extensive bibliography. There are no illustrations

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