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January 1956

Cutaneous Appearance of Porphyria by Ultraviolet Light

AMA Arch Derm. 1956;73(1):34-37. doi:10.1001/archderm.1956.01550010036003

Physicians and investigators show increasing interest in porphyria with greater awareness and knowledge of the several clinical states making up this group. Students are busy making new classifications or revising older ones as new information unfolds. Combinations of symptoms and time of appearance go to separate the several varieties of porphyria, but all have the central theme of abnormal metabolism of porphyrins. The various clinical manifestations need corroboration by evidence of excretion of abnormal kinds and amounts of porphyrins. These are mostly uroporphyrin and products that precede it.

Porphyria so commonly shows up with cutaneous symptoms as to be of interest and important to dermatologists. Some of these changes are vesiculation and blistering with consecutive lesions mild or severe and disabling. Pigmentation is common, as is hirsutism and alterations of hair growth patterns and sclerodermoid effects. Most of these alterations of the skin are at