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April 1956

Hydrocortisone Ointment Bases: Clinical Evaluation of the Effect of Eleven Different Vehicles Containing One Per Cent Hydrocortisone

Author Affiliations

Montreal, Canada

AMA Arch Derm. 1956;73(4):355-360. doi:10.1001/archderm.1956.01550040049007

The selection of ointment bases and vehicles for the incorporation of topically applied drugs has never ceased to interest the practicing physician. However, this choice, up until the present time, has been chiefly determined by tradition and by clinical impression rather than by clinical research. The recent introduction of a number of emulsifying agents has made possible the construction of numerous new formulae for both water-in-oil and oil-in-water emulsions, and absorption bases of various types. It is thus within our scope now to design a vehicle, ``made-to-order,'' which should meet all the requisites which the physician may outline for his base.1

Through the activity of pharmaceutical research, the physician has been able to eliminate vehicles with allergenic and irritating properties while achieving certain standards with regard to compatibility and stability of the various drugs and bases. Experimental studies have been concerned with the influ

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