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June 1956

Histiocytemia with Cutaneous Manifestations

Author Affiliations


From the Dermatology Service, Veterans Administration Hospital, Minneapolis, Dr. I. Fisher, Chief of Service, and from the Division of Dermatology, University of Minnesota, Dr. Henry E. Michelson, Director.

AMA Arch Derm. 1956;73(6):582-584. doi:10.1001/archderm.1956.01550060052010

This is the report of a patient who has a large number of histiocytes in the peripheral blood without evidence of malignancy, associated with a peculiar eruption characterized microscopically by dilated capillaries in the upper corium filled with histiocytes.


A 59-year-old white man was in good health until 1948, when he was hospitalized because of nausea, vomiting, diarrhea, and weight loss. The patient responded rapidly to nonspecific therapy, and a diagnosis of psychoneurosis was made.

He remained asymptomatic until February, 1953, when he developed the symptoms of an upper respiratory infection. The presence of an eruption on the nape was noted at this time. The mild respiratory symptoms disappeared, but the following symptoms persisted: anorexia, diarrhea, eruption, weight loss, and fever. The fever occurred only in the afternoon and ranged up to 101 to 103 F. Aggravation of his symptoms resulted in

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