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July 1956


AMA Arch Derm. 1956;74(1):92-94. doi:10.1001/archderm.1956.01550070094018

A clinical study of 335 cases of dermatitis treated with hydrocortisone and fludrocortisone (9α-fluorohydrocortisone) applied topically in both lotion and ointment form by the method of paired comparisons was begun Sept. 28, 1954, and is still being continued. Fludrocortisone was supplied for this study in strengths of 0.1% and 0.25% in lotion form in ½ oz. (15 cc.) plastic bottles and in strengths of 0.1%, 0.25%, and 0.5% in ointment form. Corresponding strengths of 1% and 2.5% hydrocortisone in identical vehicles were used for paired comparison with the fludrocortisone preparations. The vehicles were also supplied in similar containers for placebo comparison.


Patients with selected dermatoses in private office practice were given pairs of the corticoid preparations, the fludrocortisone being 1/10 as strong as the hydrocortisone. They were instructed to apply the lotion or ointment thrice daily to the affected areas. In most cases simultaneous contralateral applications were