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August 1956

Multiple Neurofibromatosis

AMA Arch Derm. 1956;74(2):208. doi:10.1001/archderm.1956.01550080094017

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This book is more than a summation of the literature on the subject; rather it is built specifically around a study conducted at the University of Michigan, by both the Department of Dermatology and the Heredity Clinic, of 223 persons with neurofibromatosis. The focal points of the study were the clinical and pathological aspects and the genetics of neurofibromatosis. Among the interesting and unfamiliar facts brought out were the following: approximately 78% of persons with the syndrome had at least six or more cafè-au-lait spots, whereas none of the normal adults studied had as many. Palmar and plantar neurofibromata were infrequent, but, when they occurred, they occurred as a familial pattern. It was the rare patient who did not show some osseous manifestations. Approximately 50% of the patients encountered were found to have relatives who were also affected. The book is not a ponderous statistical report; it is

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