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September 1956

Simultaneous Dyshidrosis in Monozygotic Twins During Their Separation

Author Affiliations

U. S. Army

From the Department of Dermatology, Army Medical Service Graduate School and Walter Reed Army Hospital, Walter Reed Army Medical Center, Washington, D. C.

AMA Arch Derm. 1956;74(3):250-252. doi:10.1001/archderm.1956.01550090024005

The simultaneous occurrence of dyshidrosis in monozygotic twins recorded in this report is especially noteworthy because of the unusual circumstances under which the eruptions occurred. Furthermore, these circumstances allowed an approximate evaluation in these patients of the relative roles played by intrinsic factors and external irritants in evoking or aggravating the disease, a disorder in which the fundamental etiology still remains to be clarified.

Report of Case

These 21-year-old white male twins were judged to be monozygotic on the basis of identical physical appearance. They had the same hair color and texture, similar fingerprint patterning, and similar iris markings.1 They first developed identical vesicular eruptions on their hands and fingers at the age of 14 during a period of parental strife. Their eruptions persisted with varying severity for two years, despite various local medicaments, and finally cleared simultaneously in both individuals, according to their