In 1933 Wintrobe and Buell20 reported a case of multiple myeloma with a serum protein which precipitated immediately after withdrawal from the body. Subsequently, cold-precipitable serum protein fractions have been encountered in a variety of conditions and their properties have been described.* Abnormal reactions to low temperatures, such as blanching, cyanosis, mottling, and signs of circulatory insufficiency, have been reported separately and in association with other diseases, such as multiple myeloma, leukemia, bronchiectasis, rheumatic fever, rheumatoid arthritis, and others.† The clinical manifestations have been ascribed to the physical characteristics of the cryoprotein,‡ and to an immunological reaction.21
This study illustrates the phenomenon of cold allergy manifested by urticaria, mottling of the skin, and pruritus associated with a cold-precipitable serum protein fraction. Treatment with cortisone abolished the abnormal reaction to cold and resulted in the disappearance of the cryoproteinemia.
Report of Case
WIRTSCHAFTER ZT, GAULDEN EC, WILLIAMS DW. Cold Allergy Associated with Cryoproteinemia. AMA Arch Derm. 1956;74(3):302–305. doi:10.1001/archderm.1956.01550090076016
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