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October 1956

Relapse in Discoid Lupus Erythematosus Treated with Antimalarial Drugs

AMA Arch Derm. 1956;74(4):387-388. doi:10.1001/archderm.1956.01550100055010

In a previous communication1 we pointed out that chloroquine (7-chloro-4-[4-diethylamino-1-methylbutylamino ] quinoline ) diphosphate could replace quinacrine (3-chloro-7-methoxy-9-[1 methyl-4-diethylaminobutylamino] acridine dihydrochloride) in the treatment of chronic discoid lupus erythematosus and light eruptions but stated that there was no evidence to suggest that the therapeutic effect of chloroquine would be any more permanent than that of quinacrine. Although numerous reports have appeared on the use of synthetic antimalarial drugs, there are few details available on the question of relapse after cessation of therapy. We have therefore reviewed our results of treatment with quinacrine and chloroquine with special reference to recurrence of lesions after therapy has been discontinued.

Dosage Schedule

Quinacrine.—The majority of patients received 0.1 gm. three times daily for one month, then 0.1 gm. twice daily for the next month, and finally 0.1 gm. daily for the remainder of