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October 1956

Meprobamate (Miltown) as Adjunct in Treatment of Anogenital Pruritus

Author Affiliations

New Brunswick, N. J.

The Miltown for this study was supplied by Wallace Laboratories, Inc., New Brunswick, N. J.

AMA Arch Derm. 1956;74(4):393-396. doi:10.1001/archderm.1956.01550100061012

Recently published studies* of a new tranquilizing drug called meprobamate (Miltown) reported very encouraging results with psychiatric patients, particularly with those suffering from anxiety and tension states. The drug (chemically 2-methyl-2-n-propyl-1,3-propanediol dicarbamate) was reported † to possess muscle-relaxant properties similar to those of mephenesin but of much longer duration, as well as unusual tranquilizing properties apparently related to a specific effect on the activity of the thalamus. All investigators described the drug as extremely low in toxicity and devoid of important side-effects.

Because certain dermatological syndromes have so frequently appeared closely bound up with emotional factors, the use of sedatives as an adjunct to therapy has become widespread in these conditions. Until recent years the barbiturates were most commonly used. Their usefulness, however, was limited by the fact that they dulled the sensorium and entailed the possibility of addiction. More recently

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