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October 1956


AMA Arch Derm. 1956;74(4):440-447. doi:10.1001/archderm.1956.01550100108024

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Xanthoma Tuberosum Multiplex (Familial). Presented by Dr. George C. Andrews.

A 55-year-old housewife was seen in 1954, complaining of yellowish nodules on the knees, elbows, and palms, of six years' duration. She also complained of extremely dry skin, with brittleness and loss of hair on the scalp.

Her mother died of cancer in 1947 and her father of high blood pressure in 1946. A sister was seen by me in 1948 at the age of 42. She had lesions of xanthoma tuberosum multiplex on the palms, soles, elbows, and knees. The blood cholesterol was 735 mg. per 100 cc. In 1948 she died of a heart attack. The other sister was also seen by me in 1948 at the age of 47 with the same type of lesions on the hands, palms, elbows, and knees. Her blood cholesterol was only 139 mg. per 100 cc. She has remained well, and

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