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October 1956


AMA Arch Derm. 1956;74(4):448-451. doi:10.1001/archderm.1956.01550100116025

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Sickle-Cell Anemia. Presented by Dr. Ervin Epstein, Oakland.

A 34-year-old Negro man, has had ulcers on his left lower leg for the past four months. He has known that he had sickle-cell anemia for the past two years. He has been treated with iron and vitamin B12 without much change in the blood picture. During the past three months, he has noted an active lesion on the left lower leg. When first seen on Oct. 11, 1955, this lesion was crusted and ecthymatous. One week later the crust had been removed and a rather deep, punched-out ulcer was evident. There is no family history of anemia or leg ulcers. Multiple scars of previous ulcers were also present on the left lower leg.


Dr. Ervin Epstein, Oakland: It has been found that certain factors exist in the genes that determine the exact type of congenital hemolytic anemia associated with

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