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January 1957

Dermatohistopathology of Various Types of Scleroderma

Author Affiliations

Rochester, Minn.

AMA Arch Derm. 1957;75(1):78-87. doi:10.1001/archderm.1957.01550130080008

This paper deals with the dermatohistopathologic findings in more than 200 cases of different types of scleroderma, including brief comments on pathologic findings in biopsy of specimens of muscle from many patients who had generalized forms of scleroderma. We are not concerned in this review with the systemic manifestations of the disease as it affects various internal organs*; neither will we endeavor to distinguish morphea, kraurosis, balanitis xerotica obliterans, and lichen sclerosus et atrophicus as they occur on the genitalia. The term "scleroderma of the skin" has been subject to multiple definitions and classifications,‡ and although some group all forms of scleroderma together, we prefer to recognize the following types as having certain characteristics that distinguish one from another.


We classify scleroderma as follows:

I. Generalized forms of scleroderma (associated with a varying degree of systemic involvement).

A. Generalized or diffuse type. This

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