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January 1957

Adenoacanthoma: A Dyskeratotic Squamous-Cell Carcinoma with Tubular and Alveolar Formations

Author Affiliations

Durham, N. C.

From the Division of Dermatology and Syphilology, Department of Medicine, Duke University School of Medicine.

AMA Arch Derm. 1957;75(1):96-100. doi:10.1001/archderm.1957.01550130098010


Carcinomas believed to be of eccrine sweat gland origin with glandular as well as epidermal elements have been reported by Lever under the designation adenoacanthoma of sweat glands.* It is the purpose of this paper to present two additional cases of adenoacanthoma to call attention again to this unusual but interesting entity and to comment briefly upon its clinical, histogenetic, and histopathologic features.

According to Lever, these tumors clinically resemble squamous-cell carcinomas. They show shallow ulceration and may have a verrucous surface. Their site of predilection is the face, especially the ears. Adenoacanthomas show tubular and alveolar lumina lined with one or several layers of epithelium. In areas where the lumina are lined with a single layer of epithelium, the epithelial cells have the appearance of glandular cells, but in areas with several layers of epithelium, squamous and partially keratinized cells usually form the inner

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