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January 1957

Disseminated Pathergic (Allergic) Granulomatosis: The Histopathological Picture of a Cutaneous Lesion: Report of a Case

Author Affiliations

(MC), U. S. Army Reserve

AMA Arch Derm. 1957;75(1):107-111. doi:10.1001/archderm.1957.01550130109012

A bizarre condition involving tissue changes in the respiratory tract, kidneys, and spleen was first described by Klinger1 in 1931. Subsequently the disease syndrome or a very similar syndrome consisting of extravascular granulomas and a generalized periarteritis nodosa has been described under a multiplicity of titles, the most commonly accepted being Wegener's granulomatosis2 and allergic granulomatosis.3,4 More recently, in 1955, Fienberg5 suggested pathergic granulomatosis as the best term on the basis of pathogenesis. Pathergy as defined by Rössle6 is a condition in which the application of a stimulus leaves the organism in a state in which it is unduly susceptible to subsequent stimuli of a different kind. Fienberg5 further proposed that this condition be divided into two varieties: (1) disseminated pathergic granulomatosis, and (2) a focal variety in which only a single organ or a portion of an organ is

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