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January 1957

Isoniazid in the Treatment of Acne Vulgaris

Author Affiliations

Washington, D. C.

AMA Arch Derm. 1957;75(1):129. doi:10.1001/archderm.1957.01550130131018

Because acne vulgaris, particularly in its late stage, shows pathologically a granulomatous reaction that resembles tuberculosis, we thought isoniazid might be helpful as a therapeutic agent in this disease. Accordingly, we selected a group of our patients whose acne had been recalcitrant and gave them the drug daily for periods of one to three months. Since some of these patients were helped, a few quite remarkably so, this preliminary report is being made.


The patients who were selected had moderate to severe acne with papulopustular lesions; a few had superficial punctate lesions, and some had large cysts. All patients were continued on CO2 slush therapy, and all continued to use a lotio alba locally. Some of the patients had completed courses of x-ray therapy. Since these patients had been under our observation for many months, their respective courses were well known to us,

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