In a previous communication1 the responses of the blood vessels and eccrine sweat glands of the skin of patients with atopic dermatitis to the intradermal injection of epinephrine and acetylcholine was described. It was found that an intradermal injection of epinephrine (1:10,000 and 1:100,000) produced a normal response in patients with atopic dermatitis. However, when acetylcholine (1,10,000 and 1:100,000) was injected intradermally into the skin of patients with atopic dermatitis, a "delayed blanch phenomenon" of vasoconstriction occurred rather than the normal response of vasodilatation.
It was postulated that the "delayed blanch phenomenon" was the result of the direct action of a vasoconstrictor substance on the blood vessels of the skin. It was further suggested that this hypothetical vasoconstrictor substance is either (1) acetylcholine itself producing a constrictor rather than the usual vasodilator response or (2) some other vasoconstricting substance which is released after acetylcholine
LOBITZ WC, HELLER ML, DOBSON RL. Physiologic Studies in Atopic Dermatitis (Disseminated Neurodermatitis): II. The Effect of Denervation on the "Delayed Blanch Phenomenon". AMA Arch Derm. 1957;75(2):228–229. doi:10.1001/archderm.1957.01550140072011
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