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February 1957

Hypertrophic Lichen Planus Treated by Local Injection of Prednisolone

Author Affiliations

New York

From the Department of Dermatology, College of Physicians and Surgeons, Columbia University.

AMA Arch Derm. 1957;75(2):264-265. doi:10.1001/archderm.1957.01550140108018

This report concerns the successful treatment of the hypertrophic type of lichen planus by the local injection of prednisolone suspension. Cessation of severe pruritus and the involution of hypertrophy in these lesions were accomplished in all lesions treated by this method.


A sterile aqueous suspension containing 25 mg. per cc. prednisolone* was used. It was found that the 24-gauge hypodermic needle allowed the particles in suspension to pass through without stoppage. The lesions were treated at weekly intervals, and no more than 1 cc. (25 mg.) of the prednisolone suspension was injected in one week. The amount injected into any one lesion varied from 0.3 cc. to 0.5 cc.


Three patients with typical lesions of lichen planus of the verrucous or hypertrophic type were treated. One patient was a Negro housewife, age 42, with some 30 lesions on the lower limbs, varying in size from 6