Pegum1 has drawn attention to the therapeutic implications, in vitiligo, of the dual system of melanocytes in the human skin. It frequently happens that vitiligo affects only the system situated in the basal layer of the epidermis, while that belonging to the hair bulbs and responsible for the pigmentation of hair is unaffected. In such cases, in brunets, pigmented hairs may be seen in the vitiliginous areas. On theoretical grounds Pegum postulated that "if the epidermis from a patch of vitiligo with dark hair is removed, leaving the hair roots intact, regeneration from the hair follicles should result in re-pigmentation of the patch." In attempts to produce this result epidermis was removed by the Thiersch-graft method and by various forms of blistering. Where success was achieved pigment was seen first at the hair follicles and later coalesced to cover the entire area. In one case repigmentation was
LOEWENTHAL LJA. Dermabrasion for Vitiligo. AMA Arch Derm. 1957;75(2):268. doi:10.1001/archderm.1957.01550140112021
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