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March 1957

Alopecia from Coumarin

Author Affiliations


From the Departments of Dermatology, University of Illinois College of Medicine, and Cook County Hospital.

AMA Arch Derm. 1957;75(3):440-441. doi:10.1001/archderm.1957.01550150128021

The important place of anticoagulants in medicine today makes new observations or little-known reactions to them worthy of notice. While attention of the physician is focused on the main arena of action of this group of drugs, often with anxiety, side-reactions of smaller importance may escape his notice. For this reason we are reporting the case of a child who developed a diffuse alopecia after the ingestion of a coumarin product. The experience of others shows, however, that loss of hair accompanying use of anticoagulants is common.

Report of a Case

A 2-year-old Negro girl was seen in our clinic for loss of hair. She had ingested a proprietary pesticide called "d-Con," whose active ingredient is a coumarin. Soon after this the child fell asleep. Two hours later she awakened, and complained of severe pain in the abdomen. She then vomited copiously and had diarrhea. The vomitus

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