[Skip to Navigation]
April 1957

Cutaneous Clinical Physiology During Artificial Hibernation and Neurolysis

AMA Arch Derm. 1957;75(4):562-566. doi:10.1001/archderm.1957.01550160088011

In the course of clinical investigations carried out during the years 1954-1955 with the Laborit-Huguénard1 technique of artificial hibernation and neurolysis, we have had the opportunity of studying some aspects of cutaneous physiology and pathology in a group of dermatological patients. At the same time with the same patients some endocrinological2 and neurophysiological3 studies have been carried out. A preliminary report4 was made in November, 1954.

Clinical Material and Methods

Artificial hibernation was carried out according to the Laborit-Huguénard technique during periods of from three to eight days in which the patients underwent rectal temperatures down to 29 C (84.2 F). This was done by means of continuous intravenous drip with the so-called "lytic cocktail" with phenothiazine derivatives (chlorpromazine, Diparcol, Pacatal, promethazine hydrochloride [Phenergan]); Hydergine, diphenhydramine (Benadryl), procaine, and thiopental sodium in saline or dextrose 5% solution, which the patient