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This monographic study discusses the investigative procedures used at the Dermatological Clinic of the University of Hamburg, Germany, for experimental assays of modern antituberculous drugs. The technique of the in vitro experiments, as well as the animal experiments, is described in detail. The observations made with streptomycin, p-aminosalicylic acid, thiosemicarbazone, isonicotinic acid hydrazide, and their derivatives are presented and compared. Finally, two years' clinical experience with thiosemicarbazone and isonicotinic acid hydrazide in the various forms of cutaneous tuberculosis is evaluated and compared with the results obtained in the laboratory. An extensive bibliography completes the little booklet, which is well organized and contains an abundance of information for anyone interested in the clinical and investigative aspects of antituberculous therapy.
Untersuchungen zur Chemotherapie der Hauttuberkulose: Verwertbarkeit kultureller und tierexperimenteller Ergebnisse. AMA Arch Derm. 1957;75(4):632. doi:10.1001/archderm.1957.01550160158031
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