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May 1957

Dermatologic Aspects of Congenital Spherocytic Anemia

Author Affiliations


From the Departments of Dermatology and Pathology, St. Joseph's Hospital.

AMA Arch Derm. 1957;75(5):642-646. doi:10.1001/archderm.1957.01550170010002

Leg ulcers are rarely due to congenital spherocytic anemia but they may sometimes be the presenting manifestation of the disease. Related skin lesions other than ulcer are virtually unknown. This report deals with an unusual case of an erythematous dermatosis of prolonged duration without ulceration resistant to therapy until a splenectomy was performed, together with a summary of the natural history of the ulcers known to be associated with congenital spherocytic anemia.

Report of a Case

A 46-year-old white housewife presented an eruption of both legs above the ankles of six years' duration. During the preceding year there had been progressively increasing local pruritus and generalized fatigue. Inspection of the legs disclosed a mild erythematous, indurated area involving both legs above the malleoli. At the periphery was a brownish pigmentation as in stasis dermatitis, but no varicosities were present. On closer inspection the involved area revealed punc

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