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May 1957

The C-Reactive Protein in Diseases of the Skin

Author Affiliations

Ann Arbor, Mich.

From the Veterans Administration Research Hospital, Northwestern University Medical Center, Department of Dermatology, Herbert Rattner, Chairman.

AMA Arch Derm. 1957;75(5):696-698. doi:10.1001/archderm.1957.01550170064011


The C-reactive protein is a globulin, probably formed in the liver, which appears in the sera in response to neoplasia, necrosis, and inflammation. It is not found in normal serum. Although a nonspecific indicator of infection, it is quite sensitive. It has enjoyed current usage as a more delicate index of inflammation than the sedimentation rate in acute myocardial infarction and rheumatic fever.

It has been suggested that the response to C-reactive protein may represent a threshold effect to a certain level of stimulus.1 Since inflammatory stimuli vary qualitatively and quantitatively, it would be of interest to note the provocative power of individual dermatoses with special reference to the depth of the process (epidermal, dermal, deeper tissue involvement), systemic ramifications, or complications, in eliciting a positive C-reactive protein. Accordingly, 56 hospitalized male patients, 44 white and 12 Negro, were studied.

Methods and Criteria