The fact that acute intermittent porphyria can be precipitated by various chemicals is well recognized and amply reported in the literature.1-3 The chemicals most frequently described as initiating the clinical picture of acute intermittent porphyria are the barbiturates, sulfonmethane (Sulfonal), sulfonethylmethane (Trional), alcohol, and allylisopropylacetylcarbamide (Sedormid). Waldenström4 first demonstrated that the barbiturates are capable of precipitating acute attacks of porphyria in individuals having latent porphyria but who were previously free of symptoms. In September, 1954, Linden et al.5 reported the case of a patient who had an episode typical of acute intermittent porphyria shortly after receiving chloroquine. This patient was under treatment for six years for chronic discoid lupus erythematosus. Four days after the patient was started on chloroquine therapy, 0.5 gm. daily, he developed chills, low-grade fever, vomiting, and abdominal pain. His urine turned Burgundy red, and tests were positive for uroporphyrin
DAVIS MJ, VANDER PLOEG DE. Acute Porphyria and Coproporphyrinuria Following Chloroquine Therapy: A Report of Two Cases. AMA Arch Derm. 1957;75(6):796–800. doi:10.1001/archderm.1957.01550180010003
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