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June 1957

Localized Eczema Induced by House Dust Extract Injections

AMA Arch Derm. 1957;75(6):804-805. doi:10.1001/archderm.1957.01550180018005

The possible importance of household dust or other inhalants in the causation of atopic eczema has been referred to repeatedly.1-8

The subjects of these reports have been victims of atopic eczema at the time of the study. Rostenberg5 has correctly commented that "It has been shown that alien proteins, when they get into the circulation, tend to localize preferentially in areas of preexisting inflammation. Therefore, when this patient inhales the mold, which is an alien protein, it will tend to localize preferentially in preexisting areas of inflammation, which are areas of the dermatitis. Inasmuch as the patient is sensitive to this material, an antigen-antibody union will take place at the site of deposition of the allergen; and it is not surprising that, as a consequence of such a union, the preexisting dermatitis should flare."

In the past 10 years we have observed the development

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