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June 1957

Carcinoma Developing in Chronic Acne Conglobata

Author Affiliations

Pawtucket, R. I.; Providence, R. I.

From the Department of Dermatology, Boston University School of Medicine (Herbert Mescon, M. D., Professor): Assistant Professor of Dermatology (Dr. Schiff); Instructor in Dermatology (Dr. Kern).

AMA Arch Derm. 1957;75(6):878-879. doi:10.1001/archderm.1957.01550180092024

In 1952 we reported on a case of severe acne conglobata which showed dramatic improvement following treatment with chlortetracycline (Aureomycin).1 Subsequently, however, malignant degeneration occurred. A search of the literature disclosed only one report2 of squamous-cell carcinoma arising secondary to acne conglobata. In view of the rarity of such a complication, we felt that a follow-up report on our patient was justified.

Report of a Case

The patient, a 45-year-old white man, was first seen by us in September, 1949. He stated that his cutaneous disorder had begun about 28 years before, when lesions developed on the face and posterior aspect of the neck. At the time of our examination there were papules, pustules, and many comedones present on the face, posterior neck, buttocks, and thighs; numerous thick, keloidal scars over the posterior neck, sacrum, buttocks, and thighs; pustules with scarring in the axillae,