A discussion of biopsy technique is generally limited to a consideration of the instruments to be used and the technical procedures to be carried out in the removal of a specimen for histopathologic study. This emphasis may be valid for other tissues, but when the biopsy is to be performed on the skin these technical considerations take a role secondary to the more important problem of the selection of the proper site for the biopsy, the removal of an adequate specimen, the use of the proper fixative, and the utilization of appropriate stains. The aim in performing a biopsy of the skin is to obtain a specimen for histopathologic study that will disclose information leading to the correct diagnosis. No matter how skillfully it may have been excised, a specimen obtained from an area chosen haphazardly, removed inadequately, or fixed and stained incorrectly may disclose no
CARO MR. Skin Biopsy Technique. AMA Arch Derm. 1957;76(1):9–12. doi:10.1001/archderm.1957.01550190011003
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