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July 1957

Pacinian Neurofibroma

Author Affiliations

New York

From the Department of Pathology, New York University-Bellevue Medical Center and Unity Hospital, Brooklyn.

AMA Arch Derm. 1957;76(1):65-69. doi:10.1001/archderm.1957.01550190069013

Pacinian neurofibromas are benign neoplasms composed of structures resembling Vater-Pacini corpuscles. Prichard and Custer1 described two such tumors, both in the skin. These authors found only one previous reference in the literature to this type of neurofibroma; a report by Thoma2 in 1894 of a small subcutaneous tumor of the hand. However, the description of the tumor is incomplete; clinical data are omitted, and the diagnosis is not clear. Thoma further states that Virchow was unable to relate the tumor definitely to Vater-Pacini corpuscles.

Subsequent to Thoma's report, there were other reports of tumors containing structures resembling tactile end-organs. Brögli3 described a plexiform neuroma in which he observed many bodies suggestive of Meissner and Vater-Pacini corpuscles. Scherer4 examined two such tumors; one in a patient with neurofibromatosis. Both tumors contained configurations similar to tactile end-organs. Another tumor of tactile end-organs, not further classified,