This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
To the Editor: In Dr. Stephen Rothman's report on hydrocortisone preparations, in the February, 1957, issue of the Archives, mention is made of a witness who was unable to state whether the irritation he was describing was due to hydrocortisone or the vehicle.
This incident brings up a serious problem. The dermatologists in the last few years have been deprived of exact knowledge of bases used in the drug manufacturer's products. Exact ingredients and formulas have been requested by me many times, and I have been told that the preparations are a "trade secret" or given a rather ambiguous answer as "a water-soluble base." Dermatologists used to pride themselves on exact knowledge of their medications but now are forced to do much blind prescribing. Exact information is totally lacking in the labeling of local preparations.
Also, it was a rather paradoxical situation that hydrocortisone preparations almost became nonprescription items before
Swarts WB. HYDROCORTISONE PREPARATIONS: NEED FOR EXACT KNOWLEDGE OF INGREDIENTS. AMA Arch Derm. 1957;76(1):117. doi:10.1001/archderm.1957.01550190121030
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: