In this case report of colloid milium, (a) a general review of the literature is made; (b) emphasis is placed on important work not previously mentioned in the American literature, and (c) investigation along lines suggested by this work is reported.
General Review of the Literature
In 1866 Wagner first described the condition and gave us the name colloid milium. Besnier later added another case and suggested the term colloid degeneration from collagenous or elastic tissues.1
Ferreira-Marques and van Uden2 in 1950 reviewed 60 cases in the literature and among other things concluded that colloid milium was derived from elastic fibers and that its course was not favorably influenced by vitamin C therapy, although photosensitivity did play a role. The lack of benefit from vitamin C has further been agreed to by Hailey3 and Belisario,4 Lyell and Whittle,5 Percival and Duthrie.
ALLISON JR, ALLISON JR. Colloid Milium. AMA Arch Derm. 1957;76(2):218–220. doi:10.1001/archderm.1957.01550200062013
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