During the past quarter century, a number of reports have suggested that psoriasis is induced or aggravated by altered exocrine pancreatic function. The present study is intended to clarify the exocrine role of the pancreas in psoriasis.
Ingels1 in 1953 claimed good clinical results in the majority of 36 psoriasis patients who received pancreatic enzyme replacement therapy. Earlier favorable clinical reports of Dragstedt, Becker, Stewart, Clark, and Walsh2-4 using alcoholic pancreatic extract, "lipocaic," are well known. Clinical improvement with a variety of pancreatic preparations has been reported by other investigators.5-7 At present, there are a number of commercial preparations available whose primary constituents are pancreatic enzymes, which have been said to be of value in psoriasis.
Madden and Karon8 found no significant variation in pancreatic exocrine function in psoriasis. They employed only indirect measurement through study of fecal nitrogen, fecal fat,
FARBER EM, JOHNSEN RE, SHWACHMAN H. The Exocrine Function of the Pancreas in Psoriasis. AMA Arch Derm. 1957;76(2):236–238. doi:10.1001/archderm.1957.01550200080016
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