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August 1957


AMA Arch Derm. 1957;76(2):262-267. doi:10.1001/archderm.1957.01550200106032

Pretibial Myxedema. Presented by Col. R. M. Williams, M.C.

Nine years ago a white woman aged 34 received x-ray treatment to the thyroid gland for Graves' disease. After this she was placed on thyroid therapy because of exophthalmos. Three years ago, she started developing some thickening and plaquelike lesions over the shin. These lesions have thickened progressively and now tend to form nodules. Biopsy performed two and a half years ago at Madigan Army Hospital was diagnosed histologically as myxedema. She was first seen at Letterman Army Hospital in September, 1956, where radioactive iodine uptake was 0.6%, PBI not yet reported, and cholesterol 215. She is now on treatment through the Isotope Clinic of this hospital, receiving 3 tablets of Trionine daily. A microscopic slide received from Madigan Army Hospital is presented.


Dr. M. F. Allende: Has anybody in the group had any experience with the use of

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