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To the Editor: It was with considerable interest that I read the letter from Dr. A. Kaminsky of Buenos Aires in the March, 1957, issue. The experience described was undergone personally about three years ago while I was still in the learning stage of plastic planing An area 4 in. in diameter on the right leg was refrigerated with ethyl chloride to study the subjective sensations. After exfoliation no pigment remained on an otherwise very freckled area and no reappearance is seen after three years. Subsequent inquiry in the literature revealed that J. S. Pegum (Disassociated Depigmentation in Vitiligo: Significance and Therapeutic Implications, Brit. J. Dermat. 67:348 [Oct.] 1955) showed that melanocytes of the upper skin are killed by freezing deeply whereas those of the hair follicles are usually undisturbed. This knowledge was further put to use in combining cold-dermabrasion with the psoralen treatment of vitiligo where black hair
Caver CV. SURGICAL PLANING FOR FRECKLES. AMA Arch Derm. 1957;76(3):360. doi:10.1001/archderm.1957.01550210086012
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