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October 1957

Mycosis Fungoides, Tumor Stage, Five- to Eight-Year Cures with Antimonials: A Follow-Up Report of Two Cases, with the First Complete Report of a Third Case

Author Affiliations

New York

From the Department of Dermatology and Syphilology and the New York University Post-Graduate Medical School (Dr. Marion B. Sulzberger, Chairman), and the Skin and Cancer Unit of New York University Hospital.

AMA Arch Derm. 1957;76(4):452-455. doi:10.1001/archderm.1957.01550220060011

The purpose of this contribution is to report three patients* with the tumor and infiltrated stages of mycosis fungoides as cured with antimonials without having had further treatment for about five to eight years.

Case 1.—A woman,1-5 aged 59, had generalized fungating and extensive ulcerative tumors of more than eight years' duration. She did not respond to various forms of therapy, including numerous arsenic injections and several courses of roentgen-ray exposures. Her general health was steadily and rapidly deteriorating. She responded dramatically to 10 intravenous 1% tartar emetic injections, 5 cc. each, three times weekly. This treatment was followed by 73 injections of Stibanose (the diethylaminoethanol salt of sodium antimony gluconate), 4 cc, and 42 injections of stibophen (Fuadin), 5 cc. each. The last injection was given on Jan. 13, 1949. A total of 7.80 gm. of antimony was used. The patient has had no recurrent growths since May 17, 1947, and has been completely free of lesions since Nov. 29, 1948. The large series of Stibanose and Stibophen injections was given for the purpose of clearing up residual, moderately infiltrated patches on the right leg and left buttock (Figs. 1 and 2).