Benactyzine hydrochloride (Suavitil) is a member of that group of anticholinergic substances, several of which have selective activity upon various functions of the brain. This hydrochloride of the diethylaminoethyl ester of benzilic acid is represented by the following structural formula:
The drug, first prepared in Switzerland in 1936,* was recently studied by investigators in Scandinavia, Denmark, and England.1-7 Responses of laboratory animals (in which experimental neuroses were produced by various techniques), and of human subjects and patients, supported the claim that benactyzine hydrochloride, in persons with and without psychological disorders reduces autonomic reaction to induced emotion, thereby producing a state of emotional and physical relaxation, without drowsiness. Benactyzine hydrochloride raises the threshold for external stimuli, so that the patient, in a state of tension arising from excessive strain, no longer reacts to stimuli which previously would have provoked marked irritation. He feels as
WELSH AL, EDE M. Experience with Benactyzine Hydrochloride (Suavitil) in Dermatologic Practice. AMA Arch Derm. 1957;76(4):466–470. doi:10.1001/archderm.1957.01550220074015
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